One key aspect of discarding wisely is to avoid discarding cards that could potentially be used by other players to form sets or runs. For example, if a playrummy star 41 bonuser has multiple 6s in their hand, they should think twice before discarding one of them, as it could potentially be used by another player to form a set. By being mindful of which cards to discard, players can prevent their opponents from gaining an advantage and improve their own chances of success in the game.