Your ability to form sets & runs is further enhanced by the fact that wild cards can be used as replacements for any other card. Jokers & wiapps and gamesld cards have great power, but you must use them wisely by holding onto them for the moments when your hand will benefit the most from them. You might want to hold onto a joker or wild card, for instance, until you are more certain of the sets or runs you are attempting to form.
